Performance Evaluation of Poly (ɛ-Caprolactone)/Cellulose Acetate Nanofibrous Scaffold Containing Graphene Oxide used for Neural Tissue Regeneration Potentially

A novel electroactive biocompatible nanofibrous scaffold based on poly (ε-caprolactone) (PCL)/cellulose acetate (CA) containing graphene oxide (GO) is prepared by the use of electrospinning, which is employed for neural tissue regeneration potentially. By varying GO content, the PCL/CA nanofibers including 0.5 wt. % of GO is chosen as an optimum sample with an average diameter of approximately 280 nm and electrical conductivity of around 75 µS/m. According to the functional group analysis, no chemical reaction occurred during the physical distribution of GO within the PCL/CA nanofibers. Subsequently, the wetting and mechanical properties of the optimized sample reported a water contact angle of 39 and a tensile strength of 2.5 MPa, respectively. Moreover, the electrical activity of the PCL/CA nanofibers containing 0.5 wt. % of GO is higher than that of without GO based on cyclic voltammetry. Finally, the cell viability, adhesion, and differentiation of PCL/CA-0.5GO nanofibrous scaffold are shown that the presence of GO leads to providing a susceptible medium for living the cells, highly spread cells alongside tight adhesion as well as remarkable cell differentiation with their deep diffusion in the interlayers of the nanofibrous scaffold.